February 2014

Michelle Arkin, PhD

Professor in Residence

My research focuses on the development of drug-like molecules that alter important biological processes. These molecules will help us understand human biology and may lead to the design of new drugs.

Name Title Institution Jeffrey Blaney, PhD Director, Computational Chemistry and Cheminformatics Genentech Robert Chalkley, PhD Adjunct Professor UCSF Mass Spectrometry Facility Sheng Ding, PhD Adjunct Professor Tsinghua University Bradford Gibson, PhD Professor and Director, Chemistry and Mass Spectrometry Core Amgen, Director, Discovery Attribute Sciences (DAS) Miriam Gochin, PhD Professor, Basic Sciences Touro University Charles Hart, PhD Adjunct Professor

Joint Faculty

Name Title Department David Agard, PhD Professor UCSF Biochemistry and Biophysics Patricia Babbitt, PhD Professor UCSF Bioengineering and Therapeutic Sciences Leslie Benet, PhD Professor UCSF Bioengineering and Therapeutic Sciences Chris Chang, PhD Professor UC Berkeley College of Chemistry Maria Correia, PhD Professor UCSF Cellular and Molecular Pharmacology Michael Evans, PhD Professor UCSF Radiology Robert Flavell, MD, PhD Assistant Professor In Residence

UCSF School of Pharmacy leads in NIH funding for 34th year in a row

Wed Feb 12, 2014

For the 34th consecutive year, the UCSF School of Pharmacy has received more research funding from the National Institutes of Health (NIH) than any other pharmacy school in the United States.

School researchers were awarded $29.2 million during the 2013 NIH fiscal year, from October 1, 2012 to September 30, 2013.

Accomplishments

The Department of Pharmaceutical Chemistry has a long and storied history of developing computational technologies for visualization of protein structures and designing mathematical tools to predict protein structures and protein/small-molecule interactions. 2010s: Computational drug design: PLOP and SEA Introduced new computational methods to accurately model proteins and complexes (Protein Local Optimization Program, PLOP) and to predict new drug activities via statistical analyses of chemical structures (Similarity Ensemble Approach, SEA). Impact

Mission

To provide innovative technologies and fundamental discoveries in mechanistic biology for health and educational benefit We see a time when powerful technologies that fuel breakthroughs in mechanistic biology accelerate success in drug discovery and the diagnostic sciences and reveal the complex biological signaling processes that underpin human health and go awry in disease.

About the Department

In the Department of Pharmaceutical Chemistry, we explore fundamental biological mechanisms and molecules of therapeutic relevance for better health, empowered by novel technologies at the interface of chemistry, physics, and computational sciences.