Faculty

In my lab, I seek to understand design principles of biological systems and how biological networks rewire during disease progression. I bring to my biology research a blend of experimental science, engineering, and mathematics. Projects in my lab integrate advance technology, experiment, machine…

My research focuses on the development of drug-like molecules that alter important biological processes. These molecules will help us understand human biology and may lead to the design of new drugs. I also chair the Department of Pharmaceutical Chemistry. Details: Administration.

My research interests focus on the development of state of the art methodologies in mass spectrometry for use in advancing our global knowledge of human biology, specifically the dynamic, epigenetic modulation and regulation of the proteome.

I focus on defining the roles and the mechanisms of enzymes in complex biological processes and on developing technologies to facilitate these studies to aid in the rapid detection, monitoring, and control of infectious disease and cancer.

My research focuses on small molecule and protein design as an approach to understanding macromolecule structure and function.

Research in the England Lab is broadly focused on developing and applying chemical probes to investigate the structure and function of signaling proteins implicated in fundamental biological processes and human diseases. Execution of these research projects typically involves a combination of…

Our group investigates mechanisms, regulation, and biological functions of methyl group addition to proteins and RNA. Methylation, a common post-transcriptional and post-translational modification, has a profound effect on the regulation of fundamental biological processes such as gene expression,…

My laboratory is working to understand how cells self-organize into tissues, how the structure of tissues help regulate cell behaviors, and how tissue structure breaks down in diseases like cancer. By understanding these processes we hope to reveal general principles contributing to cancer…

My research group studies how molecular chaperones maintain protein homeostasis. This question is important because imbalances in protein homeostasis are linked to a number of incurable diseases, including neurodegenerative disorders. Molecular chaperones regulate all aspects of a protein’s…

The Grabe lab uses computational methods to understand biological phenomena. We are primarily interested in ion and small molecule transport across cellular membranes. We wish to understand the molecular workings of ion channels and transporters as well as how these proteins work together to…

I am interested in protein structure and dynamics related to gene expression. We study changes in protein structure that occur on time scales ranging from millions of years to a millionth of a second, with a focus on basic questions of how viruses cross-species and give rise to modern pandemics or…

I am interested in understanding how macromolecular interactions sets up subcellular compartments that control signaling and nuclear domains that regulate gene function. For this goal, I am developing new fluorescence microscopy techniques and engineering new protein and cellular tools, so that the…