- Research Overview
- Chemical Biology and Medicinal Chemistry
- Chemical Biology and Medicinal Chemistry Overview
- Discovering Enzyme Substrates and Functions
- Discovering Protein Ligands to Probe and Alter Function
- Discovering Enzyme Activators
- Analyzing Mechanisms of Drug Resistance via Chemical Biology
- Analyzing Enzyme Conformational Dynamics, Substrate Binding, and Catalysis
- Effective Drug Targeting of Pathogens via Medicinal Chemistry
- Computational Chemistry and Biology
- Computational Chemistry and Biology Overview
- Modeling protein regulation via allostery and post-translational modifications
- Visualizing and integrating bioinformatics and biomolecular data
- Modeling membrane permeation to optimize pharmacokinetics
- Determining enzyme function by predicting substrate specificity
- Physical Biology
- Protein and Cellular Engineering
- Protein and Cellular Engineering Overview
- Monitoring enzyme activity and disease biomarkers
- Generating human proteome antibodies via phage display and directed evolution
- Globally analyzing and dissecting apoptosis
- Proximity tagging of protein-protein interactions
- Investigating cellular interactions in tissues
- Creating fluorescent probes targeting the genome and key bio-pathways
- De novo design of catalytic and membrane proteins
- Probing and modulating membrane proteins
The Department of Pharmaceutical Chemistry is one of three departments in the UCSF School of Pharmacy and is under the administrative oversight of the department chair, who reports to the School’s dean. The dean reports directly to the UCSF chancellor, who reports to the UC president, who is accountable to the Regents of the University of California.
The School of Pharmacy—together with the Schools of Medicine, Nursing, and Dentistry, the Graduate Division, and the UCSF Medical Center—form UCSF, which is one of 10 campuses in the University of California (UC) system.
UCSF is intensely collaborative. As a result, department faculty members work with colleagues in research and education programs across UCSF.
Chair Matt Jacobson, PhD, leads the formation of the department’s strategic direction and priorities to ensure the continued growth and development of the department and its faculty. He manages the resources required to support the department’s success and creates the conditions for a high-performing and high-functioning work environment for the department’s faculty and staff.
Jacobson and the School’s two other chairs work as a team with the dean and School administrators to ensure the School’s continuing leadership, forging collaborations with UCSF colleagues and partners in government, business, and industry to expand the breadth and relevance of the School's work.
The vice chairs are an internal advisory group appointed by the chair. Each vice chair represents a particular department research area. They explore issues and opportunities facing the department and advise the chair on direction.
- William DeGrado, PhD
- Manages faculty award nominations
- Oversees mentoring and career development of junior faculty members, working with John Gross, PhD
- Is responsible for the department's web presence and its accuracy and quality
- Leads faculty recruitment efforts in the chemical biology area collaboratively with other departments and organized research units; interviews, screens, and evaluates applicants; directs search committee activities
- John Gross, PhD
- Manages faculty service on School, campus, and departmental committees
- Provides a role in the recruitment, interviewing, screening, and evaluation of applicants and participates in search committee activities
- Supports mentoring to establish junior faculty members as independent researchers
- Susan Miller, PhD
- Facilitates education and training relative to the mission, vision, and goals of the Doctor of Pharmacy and PhD programs
- Serves as the department representative in the School of Pharmacy’s accreditation process
- The following responsibilities are handled by Chair Jacobson until a new vice chair is appointed:
- Provides oversight and leadership to enhance research in the department
- Reviews proposals for appointments and promotions of academic personnel; analyzes and advises on issues related to faculty and non-faculty academic merits, promotions, and appointment packets
- Oversees space allocation of faculty laboratories and facilities, guiding and directing the School and campus space policies