Research in my lab focuses on atomic-level mechanisms of protein regulation, protein-ligand interactions, and computer-aided drug design. My approach is to employ physics-based energy models for predictive protein modeling. Projects in my lab combine algorithm development and biological applications.
I am particularly interested in understanding the spatial organization of the genome, the architecture of protein complexes, and the regulation of membrane receptor signaling. To answer these challenging questions, we take the approach of developing new techniques that allow them to be studied by direct visualization.
My laboratory is working to understand how cells assemble into multicellular tissues, how the structure of tissues controls the behavior of individual cells, and how changes to tissue structure drive the progression of diseases like cancer. Toward these goals, we build, perturb, and model human tissues in vitro using techniques from the chemical, engineering, physical and biological sciences.
I am interested in the development of novel chemical tools that allow us to interrogate biological processes on a molecular level with the ultimate goal of developing novel therapeutic strategies for the treatment of cancer and infectious diseases.
I focus on defining the roles and the mechanisms of enzymes in complex biological processes and on developing technologies to facilitate these studies to aid in the rapid detection, monitoring, and control of infectious disease and cancer.
My research interests focus on the development of state of the art methodologies in mass spectrometry for use in advancing our global knowledge of human biology, specifically the dynamic, epigenetic modulation and regulation of the proteome.
