Consultation Services Our expert faculty are available to provide their specialized research expertise and consultation services. Lei Wang, PhD Areas of expertise:— Protein engineering with unnatural amino acids through genetic code expansion— Covalent protein therapeuticsPublications:— Expanding the Genetic Code of Escherichia Coli— Engineering the Genetic Code in Colls and Animals: Biological Considerations and Impacts— Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics— Covalent Proteins as Targeted Radionuclide Therapies Enhance Antitumor Effects Learn about the Wang Lab Jason Gestwicki Areas of expertise:— Inhibitors and Glues for Protein-Protein Interactions — Protein Homeostasis and Molecular Chaperones — High Throughput Biophysical Assays Published papers:— Pharmacological chaperone for α-crystallin partially restores transparency in cataract models — Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation— Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases — Mapping interactions with the chaperone network reveals factors that protect against tau aggregation — High-throughput screen for inhibitors of protein-protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex— Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes— High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs Learn about the Gestwicki Lab Danica Galonic Fujimori Areas of expertise:— Epigenetics and chromatin— Antibiotics and ribosome inhibitionPublished papers:— Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism— Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling — Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics— Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance Learn more about Danica Galonic Fujimori Balyn Zaro Areas of expertise— Chemical proteomics and covalent screening— Mass spectrometry— Macrophage phagocytosis Published papers:— Improved Electrophile Design for Exquisite Covalent Molecule Selectivity— Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells— Phenotypic landscape of an invasive fungal pathogen reveals its unique biology— RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry — CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy— Macrophages redeploy functional cancer cell surface proteins following phagocytosis — P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi Learn about the Zaro Lab
