In a major breakthrough, scientists at the Gladstone Institutes, led by UCSF School of Pharmacy faculty member Sheng Ding, PhD, have transformed skin cells into heart and brain cells using combinations of chemicals.
All previous work on cellular reprogramming required adding external genes to the cells, making this accomplishment an unprecedented feat. The research lays the groundwork for potentially being able to regenerate lost or damaged cells via pharmaceuticals.
Pharmaceutical Chemistry faculty members have published the following manuscripts between January and March 2016:
saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription.
Portnoy V, Lin SH, Li KH, Burlingame A, Hu ZH, Li H, Li LC. Cell Res. 2016 Mar;26(3):320-35.
