Our group investigates how drugs affect entire networks of proteins in the body at once to achieve their therapeutic effects, via computational predictions paired with experimental testing.
My research focuses on discovering and characterizing novel small molecules that can control stem cell maintenance, activation, differentiation, and reprogramming in various tissue types.
My research group studies how molecular chaperones maintain protein homeostasis. This question is important because imbalances in protein homeostasis are linked to a number of incurable diseases, including neurodegenerative disorders. Molecular chaperones regulate all aspects of a protein’s lifecycle, including its expression, folding, trafficking and degradation. However, it isn’t yet clear how we might promote the activity of chaperones to cure diseases.
